This webinar will provide updates to the KCNQ2 community regarding ongoing studies by the Channelopathy-associated Epilepsy Research Center without Walls. The main focus will be on efforts to determine the functional consequences of 80 KCNQ2 variants of unknown significance, and on investigations using human induced pluripotent stem cells (hiPSC) to create KCNQ2-mutant neurons for physiological and pharmacological testing. This work is designed to elucidate molecular and cellular defects associated with KCNQ2 variants and explore pharmacological strategies to correct these defects.

Presenter: Alfred L. George, Jr., M.D. (Northwestern University)
Co-presenter: Anne Berg, Ph.D. (Northwestern University)